BRANAM 1 GM


Each Vial Contains:
Ceftriaxone Sodium 1 g

1 Vial Rs 58

BRANAM 1 GM

Ceftriaxone is a third-generation cephalosporin antibiotic and is active against gram-positive and gram-negative bacteria. In terms of safety and efficacy, it is considered to be equivalent to cefotaxime.

  • Respiratory tract infection
  • Skin infection
  • Soft tissue infection
  • Urinary tract infection
  • Ear infection

Mechanism of action-

It binds to one or more of the penicillin-binding proteins (PBPs) and inhibits bacterial cell wall synthesiswhich in turn inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis. Cell lysis occures due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.

Pharmacokinetics-

Volume of distribution of ceftriaxone is 5.78 to 13.5 L and is 95% bound to plasma protein. About 65% is excreted in urine and remaining portion is excreted in bile. The half-life is 5.8-8.7 hours.
Common side effects of the injection includes:
  • Swelling, redness, pain, or soreness at the injection site
  • Loss of appetite
  • Nausea
  • Vomiting
  • Diarrhea
  • Headache
This injection should not be used in the following conditions:
  • Diarrhea from an infection with Clostridium difficile bacteria
  • A type of blood disorder where the red blood cells burst called hemolytic anemia
  • Liver problems
  • Disease of the gallbladder
  • Severe renal impairment
  • Yellowing of the skin in a newborn child
Following drugs may interact with ceftriaxone:
  • Argatroban
  • BCG vaccine live
  • Cholera vaccine
  • Heparin
  • Warfarin
  • Doxycycline
  • Chloramphenicol
  • Minocycline
  • Tetracycline