CETVAR-D

Paracetamol 325 mg, Phenylpherine 5 mg, Caffeine 30 mg, Diphenhydramine 25 mg

10X10 (ALU-ALU) Rs 39

CETVAR-D

This composition is used to treat the symptoms of cold and allergic reactions such as itching, running nose, watery eyes and sneezing.
This product provides all benefits like over pain and swelling or fever etc.

Paracetamol belongs to the group of analgesic class and is used to treat pain including cold and flu.
It also treats inflammation and swelling of joints and reduces fever.

Phenylephrine acts on the alpha-1 receptor and stimulates them or is used to treat hypotension.
It causes dilatation of pupils and induces vasoconstriction.

Caffeine is also known as CNS stimulant. It combats drowsiness or reduces premature new-born respiratory conditions. Caffeine is similar to the theophylline and theobromine but structurally different.

Diphenhydramine is H1 blocker. It is mainly used to treat sessional allergies such as insect bites, stings or allergies.

  • Allergic reactions
  • Fever
  • Pain

Mechanism of Action-

Paracetamol blocks the action of Cox-1 and cox-2 which is responsible for conversion of arachidonic acid into prostaglandins, prostaglandins are inflammatory mediators which responsible for inflammation and swelling.

Phenylephrine works by mediating vasoconstriction and mydriasis by acting on alpha-1 agonist.

Caffeine blocks the action of the phosphodiesterase enzymes as phosphodiesterase regulates the cell function by acting on the second messenger cAMP thus this causes lipolysis by activating lipases which promotes the release of fatty acids and glycerol.

Diphenhydramine blocks the H1 receptors located on respiratory smooth muscles and gastrointestinal tract and endothelial cells, cardiac tissues, uterus and CNS and blocks histamine mediated actions.
  • GIT disturbances
  • Restlessness
  • Dizziness
  • Allergic reactions
  • Impaired coordination
  • Fevers
  • Headache
  • Contraindicated in ulcers Contraindicated in High blood pressure
  • Contraindicated in hyperthyroidism