- Esophagitis
- Gastroesophageal reflux disease
- Zollinger-elision syndrome
- Peptic ulcers
- Duodenal ulcers
Mechanism of Action-
Pantoprazole works by binding with the H+K+ATPase pump on the parietal cells and neutralize the excess of acid produced in the stomach.
Pharmacokinetics-
Absorption-
It is absorbed orally
Protein Binding-
It is 98% bound to plasma proteins
Metabolism-
It is metabolized in the liver
Excretion-
It is excreted via urine
- Nausea
- Fever
- Confusion
- Bloating
- Increased blood pressure
- Contraindicated in systemic lupus erythematosus
- Contraindicated in autoimmune disease
Precautions-
- Stop using it in severe allergic reactions
- Stop using in severe diarrhoea
- Nelfinavir
- Warfarin
- Ketoconazole
- Iron salts
- Mycophenolate mofetil