- In type-2 diabetes mellitus
Mechanism of action-
Glimepiride increases insulin secretion from the beta cells present in the islets of Langerhans by inducing depolarization i.e.by blocking the ATP-sensitive potassium channels.
Pharmacokinetics-
Absorption-
It is absorbed orally after 1 hour
Protein Binding-
It is 99% bound to plasma proteins
Metabolism-
It undergoes oxidation in the liver
Excretion-
It is excreted via urine and feces
- Nausea
- Dizziness
- Weakness
- Hypoglycaemia
- Contraindicated in people with known hypersensitivity
- Fluconazole
- Rifampin
- Duloxetine
- Rosuvastatin
- Sitagliptin