- Exercise induced bronchoconstriction
- Reliefs the symptom of allergic rhinitis
- Treatment of asthma
Mechanism of Action-
Levocetirizine inhibits the histamine by binding with H1 receptors which is responsible for smooth muscle contraction and which increases permeability of vascular endothelium.
Montelukast blocks the binding of LTD4, LTC4 and LTE4 because these inflammatory mediators responsible for bronchoconstriction, mucus secretion.
Pharmackionetics:
Levocetirizine-
It is absorbed orally
It is 96% bound to plasma proteins
It is metabolized via O-dealkylation.
It is excreted via urine and feces
Montelukast-
Montelukast is orally absorbed
Montelukast is 99% bound to plasma proteins
It is metabolized in the liver
It is excreted via feces
- Nausea
- Diarrhoea
- Vomiting
- Dryness of mouth
- Headache
- Skin rashes
- Fatigue
- Flu like symptoms
- Contraindicated in people with hepatic impairment
- Contraindicated in hypersensitivity
- Stop using it if it causes severe dizziness