MEFSAR-P


Each 5 ml contains:
Mefenamic Acid IP 50 mg
Paracetamol 125 mg

60 ML Rs 40

MEFSAR-P

Combination is used for pain relief and fever. It is used in rheumatoid arthritis, osteoarthritis and menstrual pain to relieve pain and inflammation. It is also used to treat mild to moderate pain.  It works by blocking the synthesis of prostaglandins that cause fever, pain and inflammation (redness and swelling).

  • Rheumatoid arthritis
  • Osteoarthritis
  • Dysmenorrhea
  • Mild to moderate pain
  • Inflammation
  • Fever

Mechanism of Action-

Both compounds belong to non-steroidal anti-inflammatory drugs which inhibits cyclooxygenase. Paracetamol is a derivative of acetaminophen, or paracetamol, with the molecular formula glycine, N, N-diethyl-,4-(acetylamino)phenyl ester. Paracetamol is a weak inhibition of COX-1 and COX-2, further inhibiting prostaglandin synthesis. Mefenamic acid is an anthranilic acid derivative. It exhibits anti-inflammatory, analgesic, and antipyretic activities.

Pharmacokinetics-

The combination is well orally absorbed. The volume of distribution of paracetamol and mefenamic acids are 1.29 l/kg and 1.06 L/kg respectively. Protein binding of paracetamol is very negligible and of mefenamic acid is 90%. They are metabolised in liver mainly by CYP enzymes. Paracetamol is mainly excreted in urine whereas mefenamic acid is excreted in both urine and bile as well. The half-life of propacetamol is of 3.6 h and of mefenamic acid is 2 hours.
Common side effect of the product includes:
  • Nausea
  • Vomiting, Diarrhea
  • Indigestion
  • Loss of appetite
  • Heartburn
The product should not to be used in the following conditions:
  • Liver problems
  • Severe renal impairment
  • Peptic ulcers
  • Pregnancy
Following drugs may interact with the combination:
  • Ibuprofen
  • Celecoxib
  • Duloxetine
  • Diclofenac
  • Fish oil (omega-3 polyunsaturated fatty acids)
  • Sertraline
  • Fluoxetine