OFLOSAR


Each 5 ml contains:
Ofloxacin USP 50 mg

60 ML Rs 65

OFLOSAR

Ofloxacin is an antibiotic of fluoroquinolone family of medications useful for the treatment of a number of bacterial infections. It works by interfering with the bacterium's DNA, halting DNA replication. Ofloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.

  • Pneumonia
  • Cellulitis
  • Urinary tract infections
  • Prostatitis
  • Plague
  • Infectious diarrhea
  • Multidrug resistant tuberculosis

Mechanism of Action-

DNA replication requires DNA gyrase and topoisomerase IV. DNA gyrase allows the untwisting required to replicate one DNA double helix into two. Topoisomerase IV provides stability to the unwind DNA during replication. Ofloxacin inhibits these two and inhibit DNA replication thereby inhibits normal cell division.

Pharmacokinetics-

It is well orally absorbed with the bioavailability of 98% and protein binding is 32%. It is mainly metabolised in liver and 65% to 80% of an administered oral dose of ofloxacin is excreted unchanged via urine within 48 hours of dosing. About 4-8% is excreted in feces. The half-life of ofloxacin is 9 hours.
Common side effect of the product includes:
  • Vomiting
  • Diarrhea
  • Headache
  • Rash
  • Tendon rupture
  • Numbness due to nerve damage
  • Seizures
  • Psychosis
Ofloxacin should not be used in the following conditions:
  • Pregnancy
  • Low blood sugar
  • Dehydration
  • Low amount of potassium in the blood
  • Diabetes
Avoid alcohol consumption with paracetamol suspension
Following drugs may interact with Ofloxacin:
  • Aspirin
  • Azithromycin
  • Dexamethasone
  • Erythromycin
  • Metformin
  • Warfarin
  • Procainamide
  • Amiodarone
  • Quinidine
Following drugs may interact with Ofloxacin:
  • Seizure disorder, conditions that increase your risk of seizures (such as brain/head injury, brain tumors), .
  • Nerve problems (such as peripheral neuropathy), 
  • Kidney disease, 
  • Liver disease
  • Myasthenia gravis, 
  • Joint/tendon problems (such as tendonitis, bursitis), 
  • Blood vessel problems (such as aneurysm or blockage of the aorta or other blood vessels, hardening of the arteries),