VAREB


Each Tablet Contains:
Rabeprazole Sodium 20 mg

10X10 Rs 48

VAREB

Rabeprazole is proton pump inhibitor and is usually used to treat ulcers and is belongs to the anti-ulcer category.

Rabeprazole do not have anticholinergic or antihistaminic properties whereas it is also known by antisecretory compound.

  • Peptic ulcer
  • Duodenal ulcer
  • Gastrointestinal reflux disease
  • Zollinger-Ellison syndrome

Mechanism of Action:

Rabeprazole inhibits the secretion of gastric acid in the stomach by acting on the hydrogen potassium ATPase (H+, k+ATPase) pump present on parietal cells. Rabeprazole act as prodrug, it only gets activated in the acid environment of the stomach.

Pharmacokinetics:

Absorption- It is absorbed orally and its bioavailability is about 52%
Protein Binding- It is 93% bound to plasma proteins
Metabolism- It is metabolized in the liver
Excretion- 90% of the drug is excreted via urine
  • Bloating
  • Swelling of faces and arms
  • Rapid weight gain
  • Tiredness
  • Weakness
  • Yellowing of eyes
  • Light coloured stools
  • Tingling of hands and feet’s
  • Contraindicated in liver disorders
  • Contraindicated in systemic lupus erythematous
  • Contraindicated in hypomagnesaemia
  • Aspirin
  • Ibuprofen
  • Lorazepam
  • Atorvastatin
  • Metoprolol succinate
  • Omeprazole
  • Pantoprazole
  • Paracetamol