VECOMIN-1000


Each Vial Contains:
Methylcobalamin 1000 mcg

5 in Tray Rs 49

VECOMIN-1000


Methylcobalamin is an active form of vitamin B12 that helps in synthesis of methionine and S-adenosylmethionine. It is required for integrity of myelin, neuronal function, proper red blood cell formation and DNA synthesis. The largest group of vitamin B12 deficiency is found in typical vegetarians all over the world, which can be alleviated with its analogue Methylcobalamin. It is a beneficial drug to most of the common disorders like cardiovascular disorders, diabetes, anemia, hyperhomocysteinemia and degenerative disorders. Methylcobalamin helps in the synthesis of neuronal lipids, regeneration of axonal nerves and has neuroprotective activity, which promote neurons to function in proper way and thus improves Alzheimer disease, Parkinsonism, Dementia and neuropathic syndromes. It is an approved treatment for peripheral neuropathy.

Methylcobalamin is used in the treatment of diabetic neuropathy, degenerative disorders and in the preliminary treatment of amyotropic lateral sclerosis. It has been used to treat some nutrition based disease such as dementia, rheumatoid arthritis and exerts neuronal protection by promoting regeneration to injured nerves. It antagonizes the glutamate induced neurotoxicity and also manifests analgesic effects. It alleviates pain behavior in diabetic neuropathy, low back pain, neuralgia and promotes nerve conduction. It helps the body to use fats and carbohydrates for energy.

  • Important for brain function
  • Anaemia
  • Neurological disorders
  • Cardiovascular disorders
  • Protein synthesis

Mechanism of action-

It works by functioning in the production of a compound called myelin, which covers and protect nerve fibers. Methylcobalamin rejuvenates the damaged neuron. Without enough methylcobalamin, myelin sheath does not form properly due to which nerve fibers suffers and people experience irreversible nerve damage. An intrinsic factor made in the stomach, must be present in the intestinal tract to allow its proper absorption. People lacking this factor show vitamin B12 deficiencies such as pernicious anemia (a slow and insidious process that can end in death. Pernicious anemia in fact means ‘leading to death’). Methylcobalamin is used as a cofactor in methionine transferase enzyme, an enzyme which converts aminoacid homocysteine to methionine via folate cycle.

Pharmacokinetics-

Its half-life is 6 days. It is distributed to every cell of the body upon binding to Transcobalamine II, a B-globulin carrier protein and is stored in the liver in an amount of 300- 500 microgram. It is eliminated through bile.
The product is considered generally safe however common side effects may include:
  • Mild diarrhea
  • Itching
  • Skin rash
  • Headache
  • Dizziness
Following drugs may interact with Vitamin B12:
  • Nitrates (nitroglycerin)
  • Fluorouracil
  • Chloramphenicol
  • Barbiturates (phenobarbitol)
  • Primidone
  • Pyrimethamine
  • Valproic acid
  • Hydantoins