VECOMIN-PLUS


Each Vial Contains:
Methylcobalamin 1000 MCG
Niacinamide 100 MG
Pyridoxine 100 MG

5 IN TRAY Rs 40

VECOMIN-PLUS


The injection contains 3 vitamin B which are methylcobalamin, niacinamide, and pyridoxine. Forms of vitamin B are essential for body growth and maintenance. The combination is good for growth of RBC and nerve transmission therefore can be used in conditions like anemia, nerve disorders. Methylcobalamin is an active form of vitamin B12 that helps in synthesis of methionine and S-adenosylmethionine. It is required for integrity of myelin, neuronal function, proper red blood cell formation and DNA synthesis .The largest group of vitamin B12 deficiency is found in typical vegetarians all over the world, which can be alleviated with its analogue Methylcobalamin. It is a beneficial drug to most of the common disorders like cardiovascular disorders, diabetes, anemia, hyperhomocysteinemia and degenerative disorders. Methylcobalamin helps in the synthesis of neuronal lipids, regeneration of axonal nerves and has neuroprotective activity, which promote neurons to function in proper way and thus improves Alzheimer disease, Parkinsonism, Dementia and neuropathic syndromes. It is an approved treatment for peripheral neuropathy.

  • Important for brain function
  • Anaemia
  • Neurological disorders
  • Cardiovascular disorders
  • Protein synthesis

Pharmacokinetics-

Methylcobalamin:
Its half-life is 6 days. It is distributed to every cell of the body upon binding to Transcobalamine II, a B-globulin carrier protein and is stored in the liver in an amount of 300- 500 microgram. It is eliminated through bile.

Pyridoxine:
Pyridoxine is a prodrug primarily metabolized in the liver. 
Pyridoxine main active metabolite, pyridoxal 5’-phosphate, is released into the circulation (accounting for at least 60% of circulating vitamin B6) and is highly protein bound, primarily to albumin. The total adult body pool consists of 16 to 25 mg of pyridoxine. Its half-life appears to be 15 to 20 days.
The product is considered generally safe however common side effects may include:
  • Mild diarrhea
  • Itching
  • Skin rash
  • Headache
  • Dizziness
Following drugs may interact with the combination:
  • Nitrates (nitroglycerin)
  • Fluorouracil
  • Chloramphenicol
  • Barbiturates (phenobarbitol)
  • Primidone
  • Pyrimethamine
  • Valproic acid
  • Hydantoins